Mast Cell Mucopolysaccharides

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Mast cells and intercellular mucopolysaccharides in Rous fowl sarcoma I.

The intercellular ground substance in the con nective tissue of Rous fowl sarcoma is known to be extremely viscous, with a high content of hyaluronic acid (4, 6, 7). In histological sections, this substance is found to be highly metachromatic upon staining with toluidine blue. Loomis and Pratt (5) demonstrated a metachromatic ground substance which yielded to a 2-hour incubation with hyaluronid...

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Mast Cell Leukemia with Ascites and Multiple Organs Damage

Mast Cell Leukemia (MCL), a rare subtype of systemic mastocytosis is defined by bone marrow involvement as atypical and aleukemic mast cells, if more than 20% and less than 10% of peripheral WBCs are mast cells, respectively. We met a case of aleukemic MCL presenting with anemia and ascites for 2 years, referred for BM evaluation, suspicious of leukemia. Our findings included BM involveme...

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INFLUENCE OF NERVE TISSUE-DERIVED NEUROTRANSMITTERS ON MAST CELL MIGRATION

In vitro culture systems using bone marrow cells from BALB/C mice were set up in medium supplemented with spleen-derived medium. Bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. The cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. ...

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Mast cells and histopathologic variants of basal cell carcinoma

Background and aim: The stroma of basal cell carcinoma (BCC) is rich in mast cells. Morpheaform BCC has been reported to contain much more mast cells than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of mast cells related to BCC and possible relationship between increased number of mast cells and clinical and histological p...

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Mast cell and atopy

INTRODUCTION During the first 100 years after Paul Ehrlich discovered them, mast cells were believed to be a component of connective tissue that was derived from undifferentiated mesenchymal cells. However, Kitamura and co-workers 2 demonstrated that mast cells (MCs) arise from multipotent hematopoietic progenitors in bone marrow. These cells took their name from the Greek word mastzellen, mean...

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ژورنال

عنوان ژورنال: Nature

سال: 1966

ISSN: 0028-0836,1476-4687

DOI: 10.1038/211422a0